The race is sponsored by the Roxbury Congregational Church, the Roxbury Recreation Commission and the weekly Roxbury road race series.
Last year's event generated a combined $2,190 for the two causes.
Runners can register and pay the $10 entry fee on Thanksgiving morning from 7 to 9:20 a.m. at the Roxbury Congregational Church, along Route 317.
A children's race will start at 9 a.m.
Walkers and wheeled entrants for the 3.0-mile race will start at 9:15 a.m. and the runners will take off at 9:30 a.m.
The top overall male and female will each receive a plaque.
Refreshments will be available after the race.