The play, which opened Feb. 21, will be staged in the Emerson Performing Arts Center at the school at 99 Green Hill Road.
The original "Avenue Q" was a two-act musical with a coming-of-age parable, addressing and satirizing the issues and anxieties associated with entering adulthood.
The musical is notable for the use of puppets alongside human actors.
Because of the sensitivity of some of the issues, the original play has been modified for school audiences and performers.
"Avenue Q: School Edition" is a collaboration of the creators of "Avenue Q" and Music Theatre International, which was created to facilitate production of the musical by high school drama departments.
Most of the profanity and sexual themes have been removed.
Performers will include Harris Owens, Jaewon "Jenna" Lee, Jacob Kantor, YiLin "Kitty" Yang, Wyatt Clark, Jeremy Marks, Micaela Grogan; Caroline Beckmann, Jeewoo Chung, Nick Weinstein, Julia Reid, Ian Riley, Hee Young "Jessica" Kang, Sagine Corrielus, Sofya "Sonya" Topkaeva and Jamie Lamy.
The orchestra will consist of Murray Mast, Oksana Protenic and Kristen Richards.
Todd Santa Maria is the choreographer, Jay Bauer is the technical director, Jay Bauer and Ms. Protenic are the lighting designers, Andy Richards is the set designer and construction director, and Sean Harrington is the puppet designer.